CARDIAC MUSCLE SOCIETY
CMS Early Career Committee
Mission : Promote early career advancement for individuals focusing on cardiac muscle physiology.
1. Provide coordinated training to foster the development of trainees and early career individuals in the field of cardiac muscle physiology research
2. Promote collaborations and networking with established investigators in the field of cardiac muscle physiology research
3. Facilitate the dissemination of information for scientific advancement and career opportunities
Current activities : Early Career Presentations at the Annual CMS Meeting
Chair - Michelle Parvatiyar, PhD
Vice - Chair Jonathan Kirk, PhD
Maegen Ackermann Borzok, Ph.D
Dr. Ackermann-Borzok’s research program focuses on cytoskeletal elements of cardiac muscle necessary to maintain beat-to-beat synchrony and normal myocyte coupling. The goals of our research are threefold: 1. to define novel mechanisms of cardiac arrhythmias, 2. to understand the link between structural proteins and cardiac electrical defects, and 3. to define novel signaling mechanisms linking cytoskeletal proteins and ion channel dysfunction. These goals are accomplished through the characterization of novel proteins and investigation of known proteins with novel functions.
Email : email@example.com
Matthew A. Caporizzo, PhD
Charles S Chung, PhD
Brett Colson, PhD
Swati Dey, PhD
Department of Clinical Pharmacology Division/Medicine
Vanderbilt University Medical Center
Sudden cardiac death (SCD) claims more lives each year than all other causes of death combined. The underlying mechanisms remain unclear, precluding the design of new more effective therapies. Dr. Dey's ongoing research aims to understand the mechanistic role of oxidative tree and autonomic dysfunction, leading to SCD. The innovations of her research program lie in (1) Establishing a highly clinically relevant animal model of non-ischemic heart failure with spontaneous arrhythmic death; (2) sophisticated new tools for quantifying ROS dynamics in subcellular microdomains; (3) Cutting edge technology for integrative studies of single neurons and cardiac myocytes that then translate to the whole heart and animal; (4) designing new tools for minimally invasive video gene therapy to transform cardiac sympathetic nerve properties to modulate cardiac oxidative stress and function. Dr. Dey trained with Dr. Brain O'Rourke at Johns Hopkins University, where she dissected the mechanistic role of mitochondrial bioenergetics and oxidative stress in both the pathogenesis and potential therapy of SCD. She joined Vanderbilt University Medical Center as a tenure track Assistant Professor in 2019.
Email : firstname.lastname@example.org
Shubha Gururaja Rao, PhD
Assistant Professor of Pharmacology
Christopher N. Johnson, PhD
Michael J. Previs, PhD
Sumita Mishra, PhD
Division of Cardiology
Johns Hopkins University School of Medicine
Epidemiological studies have shown an increased association between obesity and the diagnosis of Heart Failure with Preserved Ejection Fraction (HFpEF). HFpEF accounts for about half of all heart failure cases in USA and worldwide. There is no effective evidence-based therapy against it. Dr. Mishra’s research is focused on elucidating the mechanisms and targeting the key regulators of cardiac dysfunction in HFpEF and associated cardiometabolic disorders.
She is a faculty at the Division of Cardiology, Johns Hopkins University School of Medicine, working with Dr. David Kass. By using multidisciplinary approaches and developing relevant preclinical models that capture features of hemodynamic and metabolic stress seen in HFpEF patients, Dr. Mishra is testing novel ways to stimulate cGMP/PKG signaling as a potential approach for HFpEF treatment. She is also working towards deciphering novel mechanisms by which myocardial lipid overload effects cardiac mechanotransduction and the upstream mechanisms that alters mitochondrial dynamics in the development of cardiometabolic diseases.