CARDIAC MUSCLE SOCIETY
CMS Early Career Committee
Mission : Promote early career advancement for individuals focusing on cardiac muscle physiology.
1. Provide coordinated training to foster the development of trainees and early career individuals in the field of cardiac muscle physiology research
2. Promote collaborations and networking with established investigators in the field of cardiac muscle physiology research
3. Facilitate the dissemination of information for scientific advancement and career opportunities
Current activities : Early Career Presentations at the Annual CMS Meeting
Chair - Michelle Parvatiyar, PhD
Vice - Chair Jonathan Kirk, PhD
Dave Barefield, PhD
Department of Cell and Molecular Physiology
Loyola University Chicago
Dr. Dave Barefield is an Assistant Professor at Loyola University Chicago. Dave received his PhD at Loyola University Chicago under the mentorship of Sakthivel Sadayappan, PhD, and did his postdoctoral training at Northwestern University in the lab of Elizabeth McNally, MD, PhD. His research interests have focused on myofilament function in genetic cardiomyopathies, and particularly the effect of environmental and genetic modifiers on the progression and severity of these disorders. The Barefield Lab opened at Loyola University Chicago in May 2020 and focuses on atrial myopathies and the roll of atrial dysfunction in common forms of cardiovascular disease.
Maegen Ackermann Borzok, Ph.D
Dr. Ackermann-Borzok’s research program focuses on cytoskeletal elements of cardiac muscle necessary to maintain beat-to-beat synchrony and normal myocyte coupling. The goals of our research are threefold: 1. to define novel mechanisms of cardiac arrhythmias, 2. to understand the link between structural proteins and cardiac electrical defects, and 3. to define novel signaling mechanisms linking cytoskeletal proteins and ion channel dysfunction. These goals are accomplished through the characterization of novel proteins and investigation of known proteins with novel functions.
Email : firstname.lastname@example.org
Matthew A. Caporizzo, PhD
Charles S Chung, PhD
Brett Colson, PhD
Swati Dey, PhD
Department of Clinical Pharmacology Division/Medicine
Vanderbilt University Medical Center
Sudden cardiac death (SCD) claims more lives each year than all other causes of death combined. The underlying mechanisms remain unclear, precluding the design of new more effective therapies. Dr. Dey's ongoing research aims to understand the mechanistic role of oxidative tree and autonomic dysfunction, leading to SCD. The innovations of her research program lie in (1) Establishing a highly clinically relevant animal model of non-ischemic heart failure with spontaneous arrhythmic death; (2) sophisticated new tools for quantifying ROS dynamics in subcellular microdomains; (3) Cutting edge technology for integrative studies of single neurons and cardiac myocytes that then translate to the whole heart and animal; (4) designing new tools for minimally invasive video gene therapy to transform cardiac sympathetic nerve properties to modulate cardiac oxidative stress and function. Dr. Dey trained with Dr. Brain O'Rourke at Johns Hopkins University, where she dissected the mechanistic role of mitochondrial bioenergetics and oxidative stress in both the pathogenesis and potential therapy of SCD. She joined Vanderbilt University Medical Center as a tenure track Assistant Professor in 2019.
Email : email@example.com
Shubha Gururaja Rao, PhD
Assistant Professor of Pharmacology
Christopher N. Johnson, PhD
Sumita Mishra, PhD
Division of Cardiology
Johns Hopkins University School of Medicine
Epidemiological studies have shown an increased association between obesity and the diagnosis of Heart Failure with Preserved Ejection Fraction (HFpEF). HFpEF accounts for about half of all heart failure cases in USA and worldwide. There is no effective evidence-based therapy against it. Dr. Mishra’s research is focused on elucidating the mechanisms and targeting the key regulators of cardiac dysfunction in HFpEF and associated cardiometabolic disorders.
She is a faculty at the Division of Cardiology, Johns Hopkins University School of Medicine, working with Dr. David Kass. By using multidisciplinary approaches and developing relevant preclinical models that capture features of hemodynamic and metabolic stress seen in HFpEF patients, Dr. Mishra is testing novel ways to stimulate cGMP/PKG signaling as a potential approach for HFpEF treatment. She is also working towards deciphering novel mechanisms by which myocardial lipid overload effects cardiac mechanotransduction and the upstream mechanisms that alters mitochondrial dynamics in the development of cardiometabolic diseases.
Mary Papadaki, PhD
Cell and Molecular Physiology
Loyola University Chicago, Maywood
Mary completed her PhD at Imperial College London under the supervision of Prof Steve Marston, where she studied molecular mechanisms of inherited cardiomyopathies. She is currently a Research Assistant Professor at Loyola University Chicago and her research focuses on the interface between diabetes and cardiac function. More specifically, she is trying to understand how diabetes affects cardiac contractility through post-translational modifications and signaling pathways. Outside of science, Mary loves to run, ski, cook, and relax at the beach.
Michael J. Previs, PhD
Christopher Toepfer, PhD
'Sir Henry Wellcome Fellow of the Wellcome Trust and Oxford BHF CRE Intermediate Transition Fellow
Department of Cardiovascular Medicine
University of Oxford
Chris completed his PhD at Imperial College London under the supervision of Professor Michael Ferenczi and Dr. James Sellers (NHLBI, NIH). Studying cardiac muscle regulation in health and disease. He subsequently began a Post-doc with the support of a Sir Henry Wellcome Post-Doctoral Fellowship with Professors Christine and Jonathan Seidman at Harvard Medical School and Professor Hugh Watkins at the RDM Oxford.
Chris is currently supported by a British Heart Foundation Centre of Research Excellence (CRE) Intermediate Transition Fellowship In Oxford. Chris’s group focuses on investigating the role of thick filament variants in hypertrophic cardiomyopathy (HCM). His laboratory focuses on CRISPR/Cas-9 engineering of human induced pluripotent stem cells. These cells can be differentiated into cardiomyocytes, which are used to model human heart disease in a dish.
Early Career Committee Alumni
Jennifer Davis, PhD
University of Washington
Deeptankar DeMazumder, MD, PhD
University of Cincinnati
Benjamin Prosser, PhD
University of Pennsylvania